IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Clin Exp Med 2010;3(4):283-292

Review Article
Peroxisome proliferator activated receptor-γ and traumatic brain injury

Lei Qi, Asha Jacob, Ping Wang, Rongqian Wu

Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA; The
Feinstein Institute for Medical Research, Manhasset, NY 11030, USA; Department of Neurosurgery, First Affiliated Hospital of Medical
School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

Received August 6, 2010; accepted September 18, 2010; available online September 23, 2010

Abstract: Traumatic brain injury (TBI) represents a major health care problem and a significant socioeconomic challenge worldwide.  
No specific therapy for TBI is available.  The peroxisome proliferator activated receptor-γ (PPAR-γ) belongs to the nuclear receptor
superfamily.  Although PPAR-γ was originally characterized in adipose tissue as a regulator of lipid and glucose metabolism, recent
studies showed that PPAR-γ is present in most cell types and plays a central role in the regulation of adipogenesis, glucose
homeostasis, cellular differentiation, apoptosis and inflammation.  Here, we reviewed the current literature on the molecular
mechanisms of PPAR-γ-related neuroprotection after TBI.  Growing evidence has indicated that the beneficial effects of PPAR-γ
activation in TBI appear to be mediated through downregulation of inflammatory responses, reduction of oxidative stress, inhibition of
apoptosis, and promotion of neurogenesis.  A thorough understanding of the PPAR-γ pathway will be critical to the development of
therapeutic interventions for the treatment of patients with TBI.  (IJCEM1008001).

Keywords: Peroxisome proliferator activated receptor-γ (PPAR-γ),  traumatic brain injury (TBI), nuclear receptor superfamily,
neuroprotection, neurogenesis, oxidative stress

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Address all correspondence to:
Rongqian Wu, MD, PhD
Laboratory of Surgical Research
The Feinstein Institute for Medical Research
350 Community Drive
Manhasset, NY 11030
Tel: (516) 562-2390
Fax: (516) 562-2396
E-mail:
rwu@nshs.edu