IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Clin Exp Med 2011;4(2):157-163

Original Article
The prevalence and risk factors of decreased bone mineral density in firstly
diagnosed ulcerative colitis patients in the eastern region of turkey

Levent Ediz, Ahmet Cumhur Dülger, Murat Toprak, Mehmet Fethi Ceylan, Özgür Kemik

Yuzuncu Yil University, Medical Faculty, Physical Medicine And Rehabilitation Department, Van, Turkey; Yuzuncu Yil University, Medical
Faculty, Gastroenterology Department, Van, Turkey; Yuzuncu Yil University, Medical Faculty, Orthopaedics Department, Van, Turkey;
Yuzuncu Yil University, Medical Faculty, General Surgery Department, Van, Turkey.

Received February 26, 2011; accepted March 31, 2011; Epub April 3, 2010; published may 15, 2011

Abstract: The prevalance of osteoporosis or osteopenia in Turkish population with ulcerative colitis (UC) at the diagnosis time has not
been evaluated so far. Therefore we aimed to determine the prevelance and risk factors of decreased bone mineral density (BMD) in
UC patients at the diagnosis time in Turkey. We retrospectively evaluated dexa results, demographic and clinical characteristics, and
some biochemical markers of bone turnover of the UC patients at the diagnosis time between June 2005 and February 2010 from the
gastroenterology clinic records of the university hospital.  The study population consisted of firstly diagnosed 63 UC patients (male:
female = 27: 36; mean age 41.8 years). 38.1% at lumbar spine and 44.4% at femoral neck of the Turkish UC patients patients had low
BMD at the diagnosis time. The occurrence of osteoporosis among Turkish UC patients at the diagnosis time were 8% at lumbar spine
and 11% at femoral neck. 30.1% at lumbar spine and 33.3% at femoral neck of the patients had osteopenia at the diagnosis time.
Pearson’s coefficient of correlation showed significant correlations between low BMD and pancolitis (p<0.01), age, menopause, and
symptom duration before the diagnosis (p<0.05).In conclusion, the prevelance of low bone density at the diagnosis time in Turkish UC
patients is in accordance with Western and Eastern societies. Pancolitis, age, duration of symptoms, and menopause are predictive
factors for low bone density in these patients. (IJCEM1102009).

Keywords: Ulcerative colitis, low bone density, osteoporosis, osteopenia, prevelance, risk factors, Turkey

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Address all correspondence to:
Levent Ediz, MD, PhD
Yuzuncu Yil University Medical Faculty
Physical Medicine and Rehabilitation Department
YYU Arastirma Hastanesi, 65000, Van, Turkey.
E-mail:
leventediz@yyu.edu.tr