IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Clin Exp Med 2013;6(8):677-682

Original Article
PDLIM5 gene polymorphisms and short term antidepressant response in Chinese
major depressive disorders

Zhongchun Liu, Fan Zhu, Lihua Yao, Can Yang, Ling Xiao, Junhong Zhu, Huiling Wang, Gaohua Wang, Wanhong Liu, Zheman Xiao

Department of Psychiatry, Renmin Hospital, Wuhan University, Wuhan, China; Institute of Neuropsychiatry, Renmin Hospital, Wuhan
University, Wuhan, China; School of Basic Medical Science, Wuhan University, Wuhan, China; Wuhan Mental Health Center, Wuhan,
China. Equal contributors.

Received March 26, 2013; Accepted July 27, 2013; Epub September 1, 2013; Published September 15, 2013

Abstract: Several investigations have suggested that PDLIM5 plays a key role in the pathophysiology of major depressive disorder
(MDD), and that PDLIM5 might be a therapeutic target for the action of antidepressant. In this study, we sought to investigate whether
variations of PDLIM5 gene sequence could predict response to antidepressants in MDD patients. We selected 3 SNPs (rs10008257,
rs2433320, 2452600) of PDLIM5 gene, and performed an association analysis of PDLIM5 and the efficacy of fluoxetine treatment in 185
Han Chinese MDD patients. The results show that the rs2433320 of PDLIM5 gene are associated with fluoxetine therapeutic response
in MDD patients (X2 = 8.2960, df = 2, P = 0.0145) after correction with the Bonferroni multiple test, the HAMD score of the GG genotype
group was significantly lower than that of the AA and AG genotype group at 1, 2, 4 and 6 weeks. The results support the idea that the
PDLIM5 gene is likely to be involved in the antidepressant response in MDD. (IJCEM1303022).

Keywords: PDLIM5, antidepressant, pharmacogenetics, major depressive disorder

Address correspondence to: Dr. Zheman Xiao, Institute of Neuropsychiatry, Renmin Hospital, Wuhan University, Jiefang Road #238,
Wuhan, PR China, 430060. Tel: +86-27-88041911-88320; Fax: +86-27-88072022; E-mail: zmxiao@whu.edu.cn