IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Clin Exp Med 2010;3(1):88-94

Original Article
Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat
prefrontal cortex neurons

Xiao-Yan Qin, Jia Cui, Yan Zhang

Laboratory of Biotechnology and State Key Laboratory of Chinese ethnic minority traditional medicine, College of Life & Environmental
Science, Minzu University of China, Beijing, 100081, China, Laboratory of Neurobiology and State Key Laboratory of Biomembrane and
Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China

Received February 3, 2010, accepted March 18, 2010, available online March 20, 2010

Abstract: CE is the extract from Coeloglossum viride var.bracteatum, a plant widely used as a traditional medicine in the Southwest
China, such as Tibet. The effects of CE against amyloid toxicity in cell culture were examined in the present study. The results indicate
that CE can protect against amyloid b (Ab)25-35-induced cytotoxicity in rat primary prefrontal cortex neurons. Bcl2 and Csp3 activation
may be involved in CE protection. CE could be a promising candidate for amyloid-based Alzheimer’s disease (AD) prevention or
therapy. (IJCEM1002001).

Key words: CE, Alzheimer’s disease, Amyloid β, Coeloglossum viride var.bracteatum, traditional Chinese medicine

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Address all correspondence to:
Yan Zhang, PhD
College of Life Sciences
Beijing University
Beijing 10087, China
Tel: 86-10-62754880
E-mail:
yanzhang@pku.edu.cn