Original Article Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat prefrontal cortex neurons
Xiao-Yan Qin, Jia Cui, Yan Zhang
Laboratory of Biotechnology and State Key Laboratory of Chinese ethnic minority traditional medicine, College of Life & Environmental Science, Minzu University of China, Beijing, 100081, China, Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China
Received February 3, 2010, accepted March 18, 2010, available online March 20, 2010
Abstract: CE is the extract from Coeloglossum viride var.bracteatum, a plant widely used as a traditional medicine in the Southwest China, such as Tibet. The effects of CE against amyloid toxicity in cell culture were examined in the present study. The results indicate that CE can protect against amyloid b (Ab)25-35-induced cytotoxicity in rat primary prefrontal cortex neurons. Bcl2 and Csp3 activation may be involved in CE protection. CE could be a promising candidate for amyloid-based Alzheimer’s disease (AD) prevention or therapy. (IJCEM1002001).
Key words: CE, Alzheimer’s disease, Amyloid β, Coeloglossum viride var.bracteatum, traditional Chinese medicine