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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2011;4(4):258-264
Original Article
Reference values for echocardiographic parameters and indexes of left ventricular
function in healthy, young adult sheep used in translational research: comparison
with standardized values in humans
Paola Locatelli, Fernanda D. Olea, Andrea De Lorenzi, Fabián Salmo, Gustavo L. Vera Janavel, Anna P. Hnatiuk, Eduardo Guevara,
Alberto J. Crottogini
Department of Physiology, Favaloro University, Buenos Aires, Argentina; Echocardiography Section, Favaloro Foundation University
Hospital, Buenos Aires, Argentina.
Received July 18, 2011; accepted October 9, 2011; Epub October 22, 2011; Published November 30, 2011
Abstract: Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However,
reliable extrapolation of the results to the clinical setting requires knowing if ovine normal left ventricular (LV) function is comparable to
that of humans. We thus assessed for echocardiographic left ventricular dimensions and indexes in a large normal adult sheep
population and compared them with standardized values in normal human adults. Bidimensional and tissue Doppler
echocardiograms were performed in 69 young adult Corriedale sheep under light sedation. LV dimensions and indexes of systolic and
diastolic function were measured. Absolute and body surface area-normalized values were compared to those for normal adult
humans and their statistical distribution was assessed. Normalized dimensions (except for end diastolic diameter) as well as ejection
fraction and fractional shortening fell within the ranges established by the American Society of Echocardiography and European
Association of Echocardiography for normal adult humans. Normalized end diastolic diameter exceeded the upper normal limit but got
close to it when correcting for the higher heart mass/body surface area ratio of sheep with respect to humans. Diastolic parameters
also fell within normal human ranges except for a slightly lower mitral deceleration time. All values exhibited a Gaussian distribution.
We conclude that echocardiographic parameters of systolic and diastolic LV performance in young adult sheep can be reliably
extrapolated to the adult human, thus supporting the use of ovine models of human heart disease in translational research.
(IJCEM1107006).
Key words: Echocardiography, sheep, left ventricular function, Ovine models of heart disease
Full Text PDF
Address all correspondence to:
Dr. Alberto Crottogini
Universidad Favaloro
Solís 453, C1078AAI Buenos Aires, Argentina.
Tel: +54-11-4378-1164; fax: +54-11-4381-4959
E-mail: crottogini@favaloro.edu.ar
Original Article
Reference values for echocardiographic parameters and indexes of left ventricular
function in healthy, young adult sheep used in translational research: comparison
with standardized values in humans
Paola Locatelli, Fernanda D. Olea, Andrea De Lorenzi, Fabián Salmo, Gustavo L. Vera Janavel, Anna P. Hnatiuk, Eduardo Guevara,
Alberto J. Crottogini
Department of Physiology, Favaloro University, Buenos Aires, Argentina; Echocardiography Section, Favaloro Foundation University
Hospital, Buenos Aires, Argentina.
Received July 18, 2011; accepted October 9, 2011; Epub October 22, 2011; Published November 30, 2011
Abstract: Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However,
reliable extrapolation of the results to the clinical setting requires knowing if ovine normal left ventricular (LV) function is comparable to
that of humans. We thus assessed for echocardiographic left ventricular dimensions and indexes in a large normal adult sheep
population and compared them with standardized values in normal human adults. Bidimensional and tissue Doppler
echocardiograms were performed in 69 young adult Corriedale sheep under light sedation. LV dimensions and indexes of systolic and
diastolic function were measured. Absolute and body surface area-normalized values were compared to those for normal adult
humans and their statistical distribution was assessed. Normalized dimensions (except for end diastolic diameter) as well as ejection
fraction and fractional shortening fell within the ranges established by the American Society of Echocardiography and European
Association of Echocardiography for normal adult humans. Normalized end diastolic diameter exceeded the upper normal limit but got
close to it when correcting for the higher heart mass/body surface area ratio of sheep with respect to humans. Diastolic parameters
also fell within normal human ranges except for a slightly lower mitral deceleration time. All values exhibited a Gaussian distribution.
We conclude that echocardiographic parameters of systolic and diastolic LV performance in young adult sheep can be reliably
extrapolated to the adult human, thus supporting the use of ovine models of human heart disease in translational research.
(IJCEM1107006).
Key words: Echocardiography, sheep, left ventricular function, Ovine models of heart disease
Full Text PDF
Address all correspondence to:
Dr. Alberto Crottogini
Universidad Favaloro
Solís 453, C1078AAI Buenos Aires, Argentina.
Tel: +54-11-4378-1164; fax: +54-11-4381-4959
E-mail: crottogini@favaloro.edu.ar
