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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(3):206-210
Original Article
Effect of bone marrow transplantation on diastolic function indices
Mersedeh Karvandi, Mohammad Asadpour Piranfar, Shahrooz Yazdani, Mahshid Mehdizadeh, Abbas Hajfathali, Mehdi tabarraee
Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Received December 30, 2012; Accepted February 17, 2013; Epub March 21, 2013; Published March 31, 2013
Abstract: Introduction: High-dose chemotherapy and bone marrow transplantation result in direct and indirect changes in cardiac
function. the finding suggests a decreased left ventricular diastolic compliance after high-dose cyclophosphamide treatment, but the
effects of bone marrow transplantation (BMT) on cardiac diastolic function are less studied. We aimed to evaluate changes before and
after the procedure in cardiac diastolic function in patients undergoing BMT. Design and methods: We designed this study to evaluate
the effects of BMT on diastolic cardiac function. Patients with lymphoma (Hodgkin’s and non-Hodgkin’s), multiple myeloma, and solid
tumors who were candidates for autologous BMT were selected for the study. The patients underwent a cardiac consultation and
echocardiography before their admission for BMT. E-wave velocity and time to relaxation by tissue Doppler echocardiography in the
septal, lateral, anterior, inferior, anteroseptal, and posterior wall; and the E-wave velocity of the right ventricle (RV) were measured
before and after BMT. Result: Thirty patients fulfilled our inclusion criteria and entered the study. The mean diastolic function measures
were calculated before and after BMT. E-wave velocity in the septal, lateral, anterior, inferior, anteroseptal and posterior walls after
transplantation decreased by 19.2% (p=0.008), 14.5% (p=0.008), 22.19% (p=0.3), 18.9% (p<0.001), 21.9% (p=0.01), and 7.5% (p=0.
01), respectively. The time to relaxation decreased by 13.5%, 13.7%, 12.4%, 11.4%, 11.1%, and 13.1%, respectively, after
transplantation (p<0.001). E-wave velocity of RV decreased 15.6% after BMT (p=0.02). Conclusion: Data regarding alterations in
diastolic functioning after BMT are scarce. This study suggests that diastolic function alters after BMT. (IJCEM1212013).
Keywords: Bone marrow transplantation, echocardiography, tissue Doppler
Address correspondence to: Dr. Mohammad Asadpour Piranfar, Taleghani Hospital, Shahid Beheshti University of Medical Sciences,
Tehran, Iran. Phone: 00982123031331; Fax: 00982122432576; E-mail: mersedeh_karvandi@ipm.ir, masadpour.piranfar@gmail.com
Original Article
Effect of bone marrow transplantation on diastolic function indices
Mersedeh Karvandi, Mohammad Asadpour Piranfar, Shahrooz Yazdani, Mahshid Mehdizadeh, Abbas Hajfathali, Mehdi tabarraee
Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Received December 30, 2012; Accepted February 17, 2013; Epub March 21, 2013; Published March 31, 2013
Abstract: Introduction: High-dose chemotherapy and bone marrow transplantation result in direct and indirect changes in cardiac
function. the finding suggests a decreased left ventricular diastolic compliance after high-dose cyclophosphamide treatment, but the
effects of bone marrow transplantation (BMT) on cardiac diastolic function are less studied. We aimed to evaluate changes before and
after the procedure in cardiac diastolic function in patients undergoing BMT. Design and methods: We designed this study to evaluate
the effects of BMT on diastolic cardiac function. Patients with lymphoma (Hodgkin’s and non-Hodgkin’s), multiple myeloma, and solid
tumors who were candidates for autologous BMT were selected for the study. The patients underwent a cardiac consultation and
echocardiography before their admission for BMT. E-wave velocity and time to relaxation by tissue Doppler echocardiography in the
septal, lateral, anterior, inferior, anteroseptal, and posterior wall; and the E-wave velocity of the right ventricle (RV) were measured
before and after BMT. Result: Thirty patients fulfilled our inclusion criteria and entered the study. The mean diastolic function measures
were calculated before and after BMT. E-wave velocity in the septal, lateral, anterior, inferior, anteroseptal and posterior walls after
transplantation decreased by 19.2% (p=0.008), 14.5% (p=0.008), 22.19% (p=0.3), 18.9% (p<0.001), 21.9% (p=0.01), and 7.5% (p=0.
01), respectively. The time to relaxation decreased by 13.5%, 13.7%, 12.4%, 11.4%, 11.1%, and 13.1%, respectively, after
transplantation (p<0.001). E-wave velocity of RV decreased 15.6% after BMT (p=0.02). Conclusion: Data regarding alterations in
diastolic functioning after BMT are scarce. This study suggests that diastolic function alters after BMT. (IJCEM1212013).
Keywords: Bone marrow transplantation, echocardiography, tissue Doppler
Address correspondence to: Dr. Mohammad Asadpour Piranfar, Taleghani Hospital, Shahid Beheshti University of Medical Sciences,
Tehran, Iran. Phone: 00982123031331; Fax: 00982122432576; E-mail: mersedeh_karvandi@ipm.ir, masadpour.piranfar@gmail.com
