 | |  | |  | |  | |  | |  | |  | |  |
| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(6): 444-451
Original Article
Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser
Karina Feliú-Hemmelmann, Francisco Monsalve, César Rivera
Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca,
Chile; Unit of Physiology and Pharmacology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca,
Talca, Chile
Received March 20, 2013; Accepted May 18, 2013; Epub June 26, 2013; Published July 1, 2013
Abstract: The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity
of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4
groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion
of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced stress using movement restriction, (3)
MP group, which received only a infusion, and (4) a CONTROL group that received no treatment. The severity of the stress was obtained
by analysis of the physical parameters of body weight, thymus and spleen, and associated biomarkers with stress, corticosterone, and
glucose. Animals that consumed Melissa officinalis and Passiflora caerulea infusion had lower plasma corticosterone levels (Student’
s t test, Welch, p = 0.05), which is the most important biomarker associated with physiological stress, demonstrating a phytotherapy
effect. (IJCEM1303017).
Keywords: Aqueous extract, Melissa officinalis, Passiflora caerulea, physiological stress, CF-1 mice
Address correspondence to: Dr. César Rivera, Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of
Health Sciences, University of Talca, Talca, Chile. Phone: +56-71-201756; E-mail: contacto@cesarrivera.cl
Original Article
Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser
Karina Feliú-Hemmelmann, Francisco Monsalve, César Rivera
Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca,
Chile; Unit of Physiology and Pharmacology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca,
Talca, Chile
Received March 20, 2013; Accepted May 18, 2013; Epub June 26, 2013; Published July 1, 2013
Abstract: The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity
of physiological chronic stress induced by movement restriction in CF-1 mice. 40 CF-1 male mice, six weeks of age, were divided into 4
groups (n = 10 for each group): (1) Group RS/MP received two treatments, induced stress through movement restriction and a infusion
of Melissa officinalis and Passiflora caerulea in a dose of 200 mg/kg, (2) RS group with induced stress using movement restriction, (3)
MP group, which received only a infusion, and (4) a CONTROL group that received no treatment. The severity of the stress was obtained
by analysis of the physical parameters of body weight, thymus and spleen, and associated biomarkers with stress, corticosterone, and
glucose. Animals that consumed Melissa officinalis and Passiflora caerulea infusion had lower plasma corticosterone levels (Student’
s t test, Welch, p = 0.05), which is the most important biomarker associated with physiological stress, demonstrating a phytotherapy
effect. (IJCEM1303017).
Keywords: Aqueous extract, Melissa officinalis, Passiflora caerulea, physiological stress, CF-1 mice
Address correspondence to: Dr. César Rivera, Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of
Health Sciences, University of Talca, Talca, Chile. Phone: +56-71-201756; E-mail: contacto@cesarrivera.cl
