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| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(6): 438-443
Original Article
DNA repair gene XRCC3 Thr241Met polymorphism and glioma risk: a meta-analysis
Bao Zhao, Jingliang Ye, Bin Li, Qiang Ma, Guojun Su, Ruizhang Han
Department of Neurosurgery, CPLA No. 98 Hospital, No. 9 Chezhan Road, Huzhou 313000, Zhejiang, China. Equal contributors.
Received May 10, 2013; Accepted June 5, 2013; Epub June 26, 2013; Published July 1, 2013
Abstract: Background: The polymorphism of XRCC3 Thr241Met has been indicated to be correlated with glioma susceptibility, but
study results are still debatable. The present meta-analysis was performed to investigate the association between XRCC3 Thr241Met
polymorphism and glioma. Methods: A total of 3754 glioma patients and 4849 controls from nine separate studies were involved. The
pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) was assessed by the random-effects model. Results: The
association between XRCC3 Thr241Met polymorphism and glioma was significant in the recessive model (OR = 1.36; 95% CI, 1.02 –
1.82; P = 0.03). In a stratified analysis by the ethnicity, significantly increased risk was detected in Asians (OR = 1.93; 95% CI, 1.18 –
3.17; P = 0.009). Conclusions: In conclusion, XRCC3 Thr241Met polymorphism was implied to be associated with increased glioma
risk. More studies are needed to validate this result. (IJCEM1305003).
Keywords: Glioma, XRCC3, meta-analysis, polymorphism
Address correspondence to: Dr. Ruizhang Han, Department of Neurosurgery, CPLA No. 98 Hospital, No. 9 Chezhan Road, Huzhou
313000, Zhejiang, China. Phone: 86-0572-3269631; E-mail: 196671693@163.com
Original Article
DNA repair gene XRCC3 Thr241Met polymorphism and glioma risk: a meta-analysis
Bao Zhao, Jingliang Ye, Bin Li, Qiang Ma, Guojun Su, Ruizhang Han
Department of Neurosurgery, CPLA No. 98 Hospital, No. 9 Chezhan Road, Huzhou 313000, Zhejiang, China. Equal contributors.
Received May 10, 2013; Accepted June 5, 2013; Epub June 26, 2013; Published July 1, 2013
Abstract: Background: The polymorphism of XRCC3 Thr241Met has been indicated to be correlated with glioma susceptibility, but
study results are still debatable. The present meta-analysis was performed to investigate the association between XRCC3 Thr241Met
polymorphism and glioma. Methods: A total of 3754 glioma patients and 4849 controls from nine separate studies were involved. The
pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) was assessed by the random-effects model. Results: The
association between XRCC3 Thr241Met polymorphism and glioma was significant in the recessive model (OR = 1.36; 95% CI, 1.02 –
1.82; P = 0.03). In a stratified analysis by the ethnicity, significantly increased risk was detected in Asians (OR = 1.93; 95% CI, 1.18 –
3.17; P = 0.009). Conclusions: In conclusion, XRCC3 Thr241Met polymorphism was implied to be associated with increased glioma
risk. More studies are needed to validate this result. (IJCEM1305003).
Keywords: Glioma, XRCC3, meta-analysis, polymorphism
Address correspondence to: Dr. Ruizhang Han, Department of Neurosurgery, CPLA No. 98 Hospital, No. 9 Chezhan Road, Huzhou
313000, Zhejiang, China. Phone: 86-0572-3269631; E-mail: 196671693@163.com
