 | |  | |  | |  | |  | |  | |  | |  |
| IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Clin Exp Med 2013;6(8):700-705
Original Article
MMP-2 and DcR3 expression in esophageal cancer tissue and correlation with
patient survival
Ran Ao, Ya-Qi Du, Ying Wang, Yu-Shuai Chen, Bing-Yuan Wang
Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China
Received July 18, 2013; Accepted August 11, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Objective: This study aims to explore the expression of decoy receptor 3 (DcR3) and the matrix metalloproteinase-2 (MMP-2)
in esophageal carcinoma and their relationship with patient survival. Methods: The EnVisionTM immunohistochemistry method was
used to examine DcR3 and MMP-2 expression in 150 surgical biopsies of esophageal carcinoma. Expression level was compared
with clinical indices and with patient survival. Results: In cancer tissues, the positive expression rate of DcR3 and MMP-2 was 54.00%
and 54.67% respectively; this was higher than levels in adjacent normal tissue. DcR3 and MMP-2 were positively correlated with
carcinoma size, lymphatic metastasis, invasion degree, clinical stage and 3-year survival. DcR3 and MMP-2 were not correlated with
gender, age and tumor degree of differentiation. DcR3 and MMP-2 were positively correlated between in the two groups (r = 0.37, P <
0.01). Kaplan-Meier survival curve showed that higher rates of DcR3 and MMP-2 expression correlated with lower survival. Conclusions:
Determining DcR3 and MMP-2 expression may be useful for the diagnosis, treatment and prognosis of patients with esophageal
carcinoma. (IJCEM1307011).
Keywords: Esophageal cancer, matrix metalloproteinase-2, decoy receptor
Address correspondence to: Dr. Ran Ao, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, 155
North Nanjing Street, Shenyang 110001, China. E-mail: aoran6556@126.com
Original Article
MMP-2 and DcR3 expression in esophageal cancer tissue and correlation with
patient survival
Ran Ao, Ya-Qi Du, Ying Wang, Yu-Shuai Chen, Bing-Yuan Wang
Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China
Received July 18, 2013; Accepted August 11, 2013; Epub September 1, 2013; Published September 15, 2013
Abstract: Objective: This study aims to explore the expression of decoy receptor 3 (DcR3) and the matrix metalloproteinase-2 (MMP-2)
in esophageal carcinoma and their relationship with patient survival. Methods: The EnVisionTM immunohistochemistry method was
used to examine DcR3 and MMP-2 expression in 150 surgical biopsies of esophageal carcinoma. Expression level was compared
with clinical indices and with patient survival. Results: In cancer tissues, the positive expression rate of DcR3 and MMP-2 was 54.00%
and 54.67% respectively; this was higher than levels in adjacent normal tissue. DcR3 and MMP-2 were positively correlated with
carcinoma size, lymphatic metastasis, invasion degree, clinical stage and 3-year survival. DcR3 and MMP-2 were not correlated with
gender, age and tumor degree of differentiation. DcR3 and MMP-2 were positively correlated between in the two groups (r = 0.37, P <
0.01). Kaplan-Meier survival curve showed that higher rates of DcR3 and MMP-2 expression correlated with lower survival. Conclusions:
Determining DcR3 and MMP-2 expression may be useful for the diagnosis, treatment and prognosis of patients with esophageal
carcinoma. (IJCEM1307011).
Keywords: Esophageal cancer, matrix metalloproteinase-2, decoy receptor
Address correspondence to: Dr. Ran Ao, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, 155
North Nanjing Street, Shenyang 110001, China. E-mail: aoran6556@126.com
