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Int J Clin Exp Med 2013;6(10):880-889
Original Article
The relationship between thyroiditis and polycystic ovary syndrome: a meta-
analysis
Danfeng Du, Xuelian Li
Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai Key Laboratory of Female Reproductive
Endocrine Related Diseases, Shanghai 200011, China
Received September 25, 2013; Accepted October 25, 2013; Epub October 25, 2013; Published October 30, 2013
Abstract: Background: The link between AIT and PCOS has been reported on several studies, but it’s true pathogenesis is far from
being elucidated. In an attempt to provide evidence of the relationship between PCOS and AIT, relevant literature of AIT markers in
women with PCOS was reviewed and analyzed. Methods: PubMed, Embase, Medline, Web of Knowledge and the Cochrane trial
register were searched with English language restriction for only human beings. Data were collected and analyzed by Revman.
Results: A total of 6 studies, involving 726 PCOS patients and 879 controls, were eligible for our meta-analysis. Conculsion: The
prevalence of AIT, serum TSH, anti-TPO and anti-Tg positive rate in PCOS patients are all significantly higher than those in control
groups, which suggests PCOS may be a kind of autoimmune disease and has close association with AIT. So, It will be helpful to
assess thyroid function routinely in patients with PCOS and offer thyroid hormone replacement therapy if necessary. (IJCEM1309028).
Keywords: Polycystic ovary syndrome, thyroiditis, atuoimmune diseases, meta-analysis
Address correspondence to: Dr. Xuelian Li, Department of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai
Key Laboratory of Female Reproductive Endocrine Related Diseases, 419 Fangxie Road, Shanghai 200011, China. Fax: 33189900-
6817; E-mail: xuelianli@aliyun.com
Original Article
The relationship between thyroiditis and polycystic ovary syndrome: a meta-
analysis
Danfeng Du, Xuelian Li
Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai Key Laboratory of Female Reproductive
Endocrine Related Diseases, Shanghai 200011, China
Received September 25, 2013; Accepted October 25, 2013; Epub October 25, 2013; Published October 30, 2013
Abstract: Background: The link between AIT and PCOS has been reported on several studies, but it’s true pathogenesis is far from
being elucidated. In an attempt to provide evidence of the relationship between PCOS and AIT, relevant literature of AIT markers in
women with PCOS was reviewed and analyzed. Methods: PubMed, Embase, Medline, Web of Knowledge and the Cochrane trial
register were searched with English language restriction for only human beings. Data were collected and analyzed by Revman.
Results: A total of 6 studies, involving 726 PCOS patients and 879 controls, were eligible for our meta-analysis. Conculsion: The
prevalence of AIT, serum TSH, anti-TPO and anti-Tg positive rate in PCOS patients are all significantly higher than those in control
groups, which suggests PCOS may be a kind of autoimmune disease and has close association with AIT. So, It will be helpful to
assess thyroid function routinely in patients with PCOS and offer thyroid hormone replacement therapy if necessary. (IJCEM1309028).
Keywords: Polycystic ovary syndrome, thyroiditis, atuoimmune diseases, meta-analysis
Address correspondence to: Dr. Xuelian Li, Department of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai
Key Laboratory of Female Reproductive Endocrine Related Diseases, 419 Fangxie Road, Shanghai 200011, China. Fax: 33189900-
6817; E-mail: xuelianli@aliyun.com
