Original Article The relationship between the polymorphism of SG13S114 A/T in ALOX5AP gene and the vulnerability of carotid atherosclerosis in Chinese Han population
Xiao-Ping Jin, Ying-Lei He, Min Zhu, Xian-Fang Lin, Qiu-Yue Chen, HAN Zhao, Xiao-Ya Huang, Feng Wang
Department of Neurology, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, 317000 P. R. China
Received December 3, 2009; accepted December , 2009; available online January 1, 2010
Abstract: The purpose of this study was to determine the relationship between the polymorphism of SG13S114 A/T in ALOX5AP gene and the vulnerability of carotid atherosclerosis in Chinese Han population. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) of SG13S114 A/T in ALOX5AP gene was performed for 284 patients with atherothrombotic cerebral infarction, of which 152 cases was diagnosed with stable plaque and the other 132 cases had vulnerable plaques. We found that the frequency of SG13S114 AA genotype and A allele of ALOX5AP gene in the cases with vulnerable plaques was significantly higher than those in the cases with stable plaques. These results suggested that high expression of SG13S114 AA genotype was related to the vulnerability of carotid atherosclerosis. SG13S114 A allele may be a risk factor of vulnerable plaques.(IJCEM912001).