IJCEM Copyright © 2008-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Clin Exp Med 2010;3(1):28-32.

Original Article
The relationship between the polymorphism of SG13S114 A/T in ALOX5AP gene and
the vulnerability of carotid atherosclerosis in Chinese Han population

Xiao-Ping Jin, Ying-Lei He, Min Zhu, Xian-Fang Lin, Qiu-Yue Chen, HAN Zhao, Xiao-Ya Huang, Feng Wang

Department of Neurology, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, 317000 P. R. China

Received December 3, 2009; accepted December , 2009; available online January 1, 2010

Abstract: The purpose of this study was to determine the relationship between the polymorphism of SG13S114 A/T in ALOX5AP gene
and the vulnerability of carotid atherosclerosis in Chinese Han population. Polymerase chain reaction and restriction fragment length
polymorphism (PCR-RFLP) of SG13S114 A/T in ALOX5AP gene was performed for 284 patients with atherothrombotic cerebral
infarction, of which 152 cases was diagnosed with stable plaque and the other 132 cases had vulnerable plaques. We found that the
frequency of SG13S114 AA genotype and A allele of ALOX5AP gene in the cases with vulnerable plaques was significantly higher than
those in the cases with stable plaques. These results suggested that high expression of SG13S114 AA genotype was related to the
vulnerability of carotid atherosclerosis. SG13S114 A allele may be a risk factor of vulnerable plaques.(IJCEM912001).

Key words: 5-lipoxygenase activating protein; atherosclerosis; gene polymorphism; polymerase chain reaction

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Address all correspondence to:
Xiao-ping Jin, MD
Department of Neurology
Taizhou Hospital, Wenzhou Medical College
Taizhou, Zhejiang, 317000 P. R. China
E-mail:
271141622@qq.com